Guerrero R, Valdez Morales E, Bron R, Poole D, Reed DE, Castro J, Campaniello M, Hughes PA, Brierley S, Bunnett NW, Lomax AE, Vanner SJ (2018). American Journal of Physiology, Gastrointestinal and Liver Physiology. Increased TASK channel mediated currents underlie high fat diet-induced vagal afferent dysfunction. Park SJ, Yang Y, Wagner B, Valinsky WC, Lomax AE, Beyak MJ (2018). N euroimmune communication in health and disease. Published on June 19 in American Journal of Physiology, Gastrointestinal and Liver Physiology 317(3): G275-G284. Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor dependent and independent mechanisms. Yu Y, Villalobos-Hernandez E, Pradhananga S, Baker C, Keating C, Grundy D, Lomax AE, and Reed DE (2019). Neurogastroenterology and Motility 31(10): e13675. The impact of dietary fermentable carbohydrates on a post-inflammatory model of irritable bowel syndrome. Tuck CJ, Caminero A, Jimenez-Vargas N, Soltys CL, Jaramillo Polanco JO, Lopez-Lopez CD, Constante M, Lourenssen SR, Verdu EF, Muir JG, Lomax AE, Reed DE, Vanner SJ. American Journal of Physiology, Gastrointestinal and Liver Physiology 317(3): G363-G372. Bacterial modulation of visceral sensation: mediators and mechanisms. Lomax AE*, Pradhananga S, Sessenwein JL, O’Malley D (2019). Proceedings of the National Academy of Sciences 117 (26): 15281-15292. Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain. Jimenez-Vargas NN, Gong J, Wisdom MJ, Jensen DD, Latorre R, Hegron A, Teng S, DiCello JJ, Rajasekhar P, Veldhuis NA, Carbone SA, Yu Y, Lopez-Lopez C, Jaramillo-Polanco J, Canals M, Reed DE, Lomax AE, Schmidt BL, Leong KW, Vanner SJ, Halls ML, Bunnett NW, Poole DP (2020). Protease-dependent excitation of nodose ganglion neurons by commensal gut bacteria. Pradhananga S, Tashtush AA, Allen-Vercoe E, Petrof EO and Lomax AE (2020). Extensive collaborations with clinicians at Kingston General Hospital enables translational work using patient biopsies and microbiota. Our research on neurogenesis focuses on factors that suppress the generation of new neurons in the adult enteric nervous system. We study enteric neurons and nociceptive neurons to understand how neuroplasticity can lead to pain and altered function during disease. We also investigate the regulation of neurogenesis in the enteric nervous system. My laboratory studies how interactions between the microbiota, nervous system and the immune system can contribute to symptom generation in inflammatory bowel disease.